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Biopharmaceutical Clarification and Purification
A collection of 3M™ Zeta Plus™ Encapsulated System Filter Capsules in various sizes

Depth Filtration

A wide range of depth filters for your process needs

Depth filtration has been the most prevalent single-use clarification technology in many biopharmaceutical manufacturing processes. 3M offers easy-to-handle depth filter solutions in a variety of nominal pore sizes and media characteristics to fit your process needs.

See below to learn more about 3M™ Zeta Plus™ Depth Filters.

By format

See all 3M™ Zeta Plus™ Depth Filters

3M™ Zeta Plus™ Filter media grades are offered in a variety of formats.

  • Capsule
    • 3M™ Zeta Plus™ Encapsulated System Filter Capsules are 3M’s premier single use depth filtration system​
    • Available with either single or dual layer 3M™ Zeta Plus™ Filter Media
    • Excellent performance in throughput and filtration efficiency with proper media selection and sizing
  • Cartridge
    • 3M™ Zeta Plus™ Filter Cartridges are for use in stainless steel housings
    • Available in 8-inch, 12-inch, and 16-inch sizes
    • Multiple lenticle and construction configurations
    • 3M™ Zeta Plus™ EXT Series Filter Cartridges (dual layer cartridges) available in SP and ZB media families
  • Sheet
    • Designed for use with commercially available filter presses
    • Contact us to learn more about filter sheet options and availability

By media

See all 3M™ Zeta Plus™ Depth Filters
  • SP series media: widest range in nominal pore sizes

    3M™ Zeta Plus™ SP Series Filter Media offers the widest range of nominal pore sizes relative to other 3M™ Zeta Plus™ Filter Media offerings. SP media also has grades with larger nominal pore sizes than LA or ZB media.

  • ZB series media: higher charge

    3M™ Zeta Plus™ ZB Series Filter Media offers a higher charge level than SP or LA media. It offers single layer and dual layer grades with a smaller nominal pore size than either the SP or the LA media family.

  • LA series media: low extractables

    3M™ Zeta Plus™ LA Series Filter Media is the cleanest 3M™ Zeta Plus™ media family offered. 3M™ Zeta Plus™ LA series low aluminum (LA) filter media are designed to provide low levels of extractables, especially aluminum.

  • Activated carbon series
    3M™ Zeta Plus™ Filters with Activated Carbon Series Media have been used in a broad array of pharmaceutical manufacturing applications. Purification attributes mirror those of bulk activated carbon including decolourisation, catalyst adsorption and removal of specific polar or nonpolar contaminants and eliminate the need to handle carbon powder in bulk form.
  • VR series media

    3M™ Zeta Plus™ Filters with VR Series Media offer an economical alternative to other available technologies for reduction of viral burden. Contact us to learn about filter media recommendations for virus removal from blood plasma proteins and bioprocess derived cell culture fluids.

  • Delipid series media

    3M™ Zeta Plus™ Delipid Series Filter Media incorporates lipid-specific adsorbents for selective removal of lipids, surfactants and biological hydrophobes from human blood plasma, serum-based products, recombinant proteins and other biological fluids.

By configuration

See all 3M™ Zeta Plus™ Depth Filters
  • Single layer

    One layer of filtration media. Using two or more single layer products may be advantageous depending on the process.

  • Dual layer (EXT Series)

    3M™ Zeta Plus™ EXT Series Filter Cartridges and Capsules include two media layers of varying grades in a single lenticle. The upstream media layer has a wider nominal pore size than the tighter downstream media layer. This construction—with one grade “stacked" on another—increases the holding capacity of the filter, extends its service life, and provides enhanced clarification of biological fluids.

Need help choosing the right media, format and size for the job?

Get help with finding the optimal 3M biopharmaceutical solution for your application. Our experts can work with you to find products that will work with your process.

Ask an Expert

Fill out this form for any technical or process-related question, and an appropriate 3M Biopharmaceutical representative will contact you to answer your question or direct your request.

Female scientist with googles and in lab coat loading a 3M encapsulated system filter capsule in the 3M's encapsulated system holder

3M™ Zeta Plus™ Encapsulated System Filter Capsules

3M™ Zeta Plus™ Filters are available in a single-use encapsulated system that provides excellent performance in throughput and filtration efficiency with proper media selection and sizing.

Single-use encapsulated systems offer a variety of benefits

  • efficiency icon
    Reduces labour time for batch-to-batch change-outs
  • Elimination icon
    Eliminates cleaning validation
  • Reduction icon
    Reduces overall operating costs​
  • Infographic showing a range of 3M™ Zeta Plus™ Filters on a graph by capacity and by process volume
    Click red dots on the image for details

    Scalability

    Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

    Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

    Click red dots on the image for details
 
 
 
 
 
 
 
 
 
 
BC25

25 cm²

E0170 and E0340

E0170 (170 cm²) and E0340 (340 cm²)

E1020

1020 cm²

E16E01 or E16R01

Dual layer (EXT Series): 1.6 m²
Single layer: 2.5 m²
Shown on a 3M™ Encapsulated Holder System Pilot Scale Holder (16EZA) with 3M™ Manifold

E16E07, E16R07, E16E11, E16R11

Dual layer (EXT Series, 7 cells): up to 11.2 m²
Single layer (11 cells): up to 17.5 m²
Shown on a 3M™ Encapsulated Holder System Production Scale Holder (16EZB) with 3M™ Manifold

Scalability

Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

  • Click red dots on the image for details
    Click red dots on the image for details
 
 
 
 
 
 
 
 
 
 
BC25

25 cm²

E0170 and E0340

E0170 (170 cm²) and E0340 (340 cm²)

E1020

1020 cm²

E16E01 or E16R01

Dual layer (EXT Series): 1.6 m²
Single layer: 2.5 m²
Shown on a 3M™ Encapsulated Holder System Pilot Scale Holder (16EZA) with 3M™ Manifold

E16E07, E16R07, E16E11, E16R11

Dual layer (EXT Series, 7 cells): up to 11.2 m²
Single layer (11 cells): up to 17.5 m²
Shown on a 3M™ Encapsulated Holder System Production Scale Holder (16EZB) with 3M™ Manifold

  • Click red dots on the image for details

    Scalability

    Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

    Available in scalable capsule formats from R&D to process development, pilot and clinical production, and commercial and large-scale production.

    Click red dots on the image for details
 
 
 
 
 
 
 
 
 
 
BC25

25 cm²

E0170 and E0340

E0170 (170 cm²) and E0340 (340 cm²)

E1020

1020 cm²

E16E01 or E16R01

Dual layer (EXT Series): 1.6 m²
Single layer: 2.5 m²
Shown on a 3M™ Encapsulated Holder System Pilot Scale Holder (16EZA) with 3M™ Manifold

E16E07, E16R07, E16E11, E16R11

Dual layer (EXT Series, 7 cells): up to 11.2 m²
Single layer (11 cells): up to 17.5 m²
Shown on a 3M™ Encapsulated Holder System Production Scale Holder (16EZB) with 3M™ Manifold

  • Infographic showing the inside of a 3M™ Zeta Plus™ Encapsulated System Filter Capsule.
    Click red dots on the image for details

    Elements

    3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.

    3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.

    Click red dots on the image for details
 
 
 
 
 
 
 
 
 
 
Shell

Translucent plastic shell option (not pictured) allows for easy liquid level detection

Structure

A cam structure allows for reliable capsule-to-capsule connection

Core Design

Solid core design eliminates the need for central post and stainless-steel bands

Reduced upstream hold-up

Upstream hold-up volume is reduced to minimum

Handles

Handles designed for easy loading and unloading

Elements

3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.

  • Click red dots on the image for details
    Click red dots on the image for details
 
 
 
 
 
 
 
 
 
 
Shell

Translucent plastic shell option (not pictured) allows for easy liquid level detection

Structure

A cam structure allows for reliable capsule-to-capsule connection

Core Design

Solid core design eliminates the need for central post and stainless-steel bands

Reduced upstream hold-up

Upstream hold-up volume is reduced to minimum

Handles

Handles designed for easy loading and unloading

  • Click red dots on the image for details

    Elements

    3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.

    3M™ Zeta Plus™ Depth Filters play an important role in the clarification of cell-derived protein therapeutic products around the world.

    Click red dots on the image for details
 
 
 
 
 
 
 
 
 
 
Shell

Translucent plastic shell option (not pictured) allows for easy liquid level detection

Structure

A cam structure allows for reliable capsule-to-capsule connection

Core Design

Solid core design eliminates the need for central post and stainless-steel bands

Reduced upstream hold-up

Upstream hold-up volume is reduced to minimum

Handles

Handles designed for easy loading and unloading

Resources

Ask an expert

Fill out this form for any technical, business or process-related question, and an appropriate 3M Biopharmaceutical representative will contact you to answer your question or direct your request. ​

Request a sample

Fill out this form and a 3M Biopharmaceutical representative will contact you to help you select and receive a sample or trial based on your needs.

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